2024

Tchen J, Simon Q, Chapart L, Thaminy MK, Vibhushan S, Saveanu L, Lamri Y, Saidoune F, Pacreau E, Pellefigues C, Bex-Coudrat J, Karasuyama H, Miyake K, Hidalgo J, Fallon PG, Papo T, Blank U, Benhamou M, Hanouna G, Sacre K, Daugas E, Charles N. PD-L1- and IL-4-expressing basophils promote pathogenic accumulation of T follicular helper cells in lupus. Nat Commun. 2024 Apr 22;15(1):3389. doi: https://doi.org/10.1038/s41467-024-47691-w. PMID: 38649353

Gleeson PJ, Benech N, Chemouny J, Metallinou E, Berthelot L, da Silva J, Bex-Coudrat J, Boedec E, Canesi F, Bounaix C, Morelle W, Moya-Nilges M, Kenny J, O’Mahony L, Saveanu L, Arnulf B, Sannier A, Daugas E, Vrtovsnik F, Lepage P, Sokol H, Monteiro RC. The gut microbiota posttranslationally modifies IgA1 in autoimmune glomerulonephritis. Sci Transl Med. 2024 Mar 27;16(740):eadl6149. doi: https://doi.org/10.1126/scitranslmed.adl6149. Epub 2024 Mar 27. PMID: 38536935

Gratio V, Dayot S, Benadda S, Nicole P, Saveanu L, Voisin T, Couvineau A. Imaging flow cytometry of tumoroids: A new method for studying GPCR expression. Cytometry A. 2024 Apr;105(4):276-287. doi: https://doi.org/10.1002/cyto.a.24809. PMID: 38017661

2023

Evnouchidou I, Koumantou D, Nugue M, Saveanu L. M1-aminopeptidase family - beyond antigen-trimming activities. Curr Opin Immunol. 2023 Aug;83:102337. doi: https://doi.org/10.1016/j.coi.2023.102337. Epub 2023 May 20. PMID: 37216842 Review.

Benadda S, Nugue M, Koumantou D, Bens M, De Luca M, Pellé O, Monteiro RC, Evnouchidou I, Saveanu L. Activating FcγR function depends on endosomal-signaling platforms. iScience. 2023 Jun 9;26(7):107055. doi: https://doi.org/10.1016/j.isci.2023.107055. eCollection 2023 Jul 21. PMID: 37360697

2022

Bratti M, Vibhushan S, Longé C, Koumantou D, Ménasché G, Benhamou M, Varin-Blank N, Blank U, Saveanu L, Ben Mkaddem S. Insulin-regulated aminopeptidase contributes to setting the intensity of FcR-mediated inflammation. Front Immunol. 2022 Oct 27;13:1029759. doi: https://doi.org/10.3389/fimmu.2022.1029759. eCollection 2022. PMID: 36389775

2021

Drajac C, Laubreton D, Marquant Q, Chottin C, Ferret C, Bouguyon E, Schwartz-Cornil I, Saveanu L, Riffault S, Descamps D. Control of IFN-I responses by the aminopeptidase IRAP in neonatal C57BL/6 alveolar macrophages during RSV infection. Mucosal Immunol. 2021 Jul;14(4):949-962. https://doi.org/10.1038/s41385-021-00402-w. Epub 2021 Apr 12. PMID: 33846534

Evnouchidou, I., Caillens, V., Koumantou, D., & Saveanu, L. (2021). The role of endocytic trafficking in antigen T Cell Receptor activation. Biomedical Journal, S2319-4170(21)00129-3. https://doi.org/10.1016/j.bj.2021.09.004

2020

Drajac, C., Laubreton, D., Marquant, Q., Chottin, C., Ferret, C., Bouguyon, E., Schwartz-Cornil, I., Saveanu, L., Riffault, S., & Descamps, D. (2021). Control of IFN-I responses by the aminopeptidase IRAP in neonatal C57BL/6 alveolar macrophages during RSV infection. Mucosal Immunology, 14(4), 949–962. https://doi.org/10.1038/s41385-021-00402-w

Evnouchidou, I., Nugue, M., & Saveanu, L. (2020). [Endosomal signaling by the TCR ζ chain is required for T lymphocyte survival in secondary lymphoid organs]. Medecine Sciences: M/S, 36(12), 1213–1215. https://doi.org/10.1051/medsci/2020235

Wan, J., Weiss, E., Ben Mkaddem, S., Mabire, M., Choinier, P.-M., Thibault-Sogorb, T., Hegde, P., Bens, M., Broer, L., Gilgenkrantz, H., Moreau, R., Saveanu, L., Codogno, P., Monteiro, R. C., & Lotersztajn, S. (2020). LC3-associated phagocytosis in myeloid cells, a fireman that restrains inflammation and liver fibrosis, via immunoreceptor inhibitory signaling. Autophagy, 16(8), 1526–1528. https://doi.org/10.1080/15548627.2020.1770979

Evnouchidou, I., Chappert, P., Benadda, S., Zucchetti, A., Weimershaus, M., Bens, M., Caillens, V., Koumantou, D., Lotersztajn, S., van Endert, P., Davoust, J., Guermonprez, P., Hivroz, C., Gross, D. A., & Saveanu, L. (2020). IRAP-dependent endosomal T cell receptor signalling is essential for T cell responses. Nature Communications, 11(1), 2779. https://doi.org/10.1038/s41467-020-16471-7

Wan, J., Weiss, E., Ben Mkaddem, S., Mabire, M., Choinier, P.-M., Picq, O., Thibault-Sogorb, T., Hegde, P., Pishvaie, D., Bens, M., Broer, L., Gilgenkrantz, H., Moreau, R., Saveanu, L., Codogno, P., Monteiro, R. C., & Lotersztajn, S. (2020). LC3-associated phagocytosis protects against inflammation and liver fibrosis via immunoreceptor inhibitory signaling. Science Translational Medicine, 12(539), eaaw8523. https://doi.org/10.1126/scitranslmed.aaw8523

Descamps, D., Evnouchidou, I., Caillens, V., Drajac, C., Riffault, S., van Endert, P., & Saveanu, L. (2020). The Role of Insulin Regulated Aminopeptidase in Endocytic Trafficking and Receptor Signaling in Immune Cells. Frontiers in Molecular Biosciences, 7, 583556. https://doi.org/10.3389/fmolb.2020.583556

Weimershaus, M., Mauvais, F.-X., Evnouchidou, I., Lawand, M., Saveanu, L., & van Endert, P. (2020). IRAP Endosomes Control Phagosomal Maturation in Dendritic Cells. Frontiers in Cell and Developmental Biology, 8, 585713. https://doi.org/10.3389/fcell.2020.585713

2019

Lawand, M., Evnouchidou, I., Baranek, T., Montealegre, S., Tao, S., Drexler, I., Saveanu, L., Si-Tahar, M., & van Endert, P. (2019). Impact of the TAP-like transporter in antigen presentation and phagosome maturation. Molecular Immunology, 113, 75–86. https://doi.org/10.1016/j.molimm.2018.06.268

Saveanu, L., Zucchetti, A. E., Evnouchidou, I., Ardouin, L., & Hivroz, C. (2019). Is there a place and role for endocytic TCR signaling? Immunological Reviews, 291(1), 57–74. https://doi.org/10.1111/imr.12764

2018

Weimershaus, M., Mauvais, F.-X., Saveanu, L., Adiko, C., Babdor, J., Abramova, A., Montealegre, S., Lawand, M., Evnouchidou, I., Huber, K. J., Chadt, A., Zwick, M., Vargas, P., Dussiot, M., Lennon-Dumenil, A. M., Brocker, T., Al-Hasani, H., & van Endert, P. (2018). Innate Immune Signals Induce Anterograde Endosome Transport Promoting MHC Class I Cross-Presentation. Cell Reports, 24(13), 3568–3581. https://doi.org/10.1016/j.celrep.2018.08.041

Aksoy, E., Saveanu, L., & Manoury, B. (2018). The Isoform Selective Roles of PI3Ks in Dendritic Cell Biology and Function. Frontiers in Immunology, 9, 2574. https://doi.org/10.3389/fimmu.2018.02574

2017

Babdor, J., Descamps, D., Adiko, A. C., Tohmé, M., Maschalidi, S., Evnouchidou, I., Vasconcellos, L. R., De Luca, M., Mauvais, F.-X., Garfa-Traore, M., Brinkmann, M. M., Chignard, M., Manoury, B., & Saveanu, L. (2017). IRAP+ endosomes restrict TLR9 activation and signaling. Nature Immunology, 18(5), 509–518. https://doi.org/10.1038/ni.3711

2016

Saveanu, L., & Lotersztajn, S. (2016). New pieces in the complex puzzle of aberrant vacuolation. Focus on “Active vacuolar H+ ATPase and functional cycle of Rab5 are required for the vacuolation defect triggered by PtdIns(3,5)P2 loss under PIKfyve or Vps34 deficiency.” American Journal of Physiology. Cell Physiology, 311(3), C363-365. https://doi.org/10.1152/ajpcell.00215.2016

Older publications

Keller, M., Ebstein, F., Bürger, E., Textoris-Taube, K., Gorny, X., Urban, S., Zhao, F., Dannenberg, T., Sucker, A., Keller, C., Saveanu, L., Krüger, E., Rothkötter, H.-J., Dahlmann, B., Henklein, P., Voigt, A., Kuckelkorn, U., Paschen, A., Kloetzel, P.-M., & Seifert, U. (2015). The proteasome immunosubunits, PA28 and ER-aminopeptidase 1 protect melanoma cells from efficient MART-126-35 -specific T-cell recognition. European Journal of Immunology, 45(12), 3257–3268. https://doi.org/10.1002/eji.201445243

Sun, J., Furio, L., Mecheri, R., van der Does, A. M., Lundeberg, E., Saveanu, L., Chen, Y., van Endert, P., Agerberth, B., & Diana, J. (2015). Pancreatic β-Cells Limit Autoimmune Diabetes via an Immunoregulatory Antimicrobial Peptide Expressed under the Influence of the Gut Microbiota. Immunity, 43(2), 304–317. https://doi.org/10.1016/j.immuni.2015.07.013 Adiko, A. C., Babdor, J., Gutiérrez-Martínez, E., Guermonprez, P., & Saveanu, L. (2015). Intracellular Transport Routes for MHC I and Their Relevance for Antigen Cross-Presentation. Frontiers in Immunology, 6, 335. https://doi.org/10.3389/fimmu.2015.00335

Gutiérrez-Martínez, E., Planès, R., Anselmi, G., Reynolds, M., Menezes, S., Adiko, A. C., Saveanu, L., & Guermonprez, P. (2015). Cross-Presentation of Cell-Associated Antigens by MHC Class I in Dendritic Cell Subsets. Frontiers in Immunology, 6, 363. https://doi.org/10.3389/fimmu.2015.00363

Evnouchidou, I., Weimershaus, M., Saveanu, L., & van Endert, P. (2014). ERAP1-ERAP2 dimerization increases peptide-trimming efficiency. Journal of Immunology (Baltimore, Md.: 1950), 193(2), 901–908. https://doi.org/10.4049/jimmunol.1302855

Papakyriakou, A., Zervoudi, E., Theodorakis, E. A., Saveanu, L., Stratikos, E., & Vourloumis, D. (2013). Novel selective inhibitors of aminopeptidases that generate antigenic peptides. Bioorganic & Medicinal Chemistry Letters, 23(17), 4832–4836. https://doi.org/10.1016/j.bmcl.2013.07.024

Saveanu, L., Babdor, J., Lawand, M., & van Endert, P. (2013). Insulin-regulated aminopeptidase and its compartment in dendritic cells. Molecular Immunology, 55(2), 153–155. https://doi.org/10.1016/j.molimm.2012.10.013

Weimershaus, M., Evnouchidou, I., Saveanu, L., & van Endert, P. (2013). Peptidases trimming MHC class I ligands. Current Opinion in Immunology, 25(1), 90–96. https://doi.org/10.1016/j.coi.2012.10.001

Saveanu, L., & van Endert, P. (2013). Preparing antigens suitable for cross-presentation assays in vitro and in vivo. Methods in Molecular Biology (Clifton, N.J.), 960, 389–400. https://doi.org/10.1007/978-1-62703-218-6_29

Weimershaus, M., Maschalidi, S., Sepulveda, F., Manoury, B., van Endert, P., & Saveanu, L. (2012). Conventional dendritic cells require IRAP-Rab14 endosomes for efficient cross-presentation. Journal of Immunology (Baltimore, Md.: 1950), 188(4), 1840–1846. https://doi.org/10.4049/jimmunol.1101504

Saveanu, L., & van Endert, P. (2012). The role of insulin-regulated aminopeptidase in MHC class I antigen presentation. Frontiers in Immunology, 3, 57. https://doi.org/10.3389/fimmu.2012.00057

Merzougui, N., Kratzer, R., Saveanu, L., & van Endert, P. (2011). A proteasome-dependent, TAP-independent pathway for cross-presentation of phagocytosed antigen. EMBO Reports, 12(12), 1257–1264. https://doi.org/10.1038/embor.2011.203

Saveanu, L., Carroll, O., Weimershaus, M., Guermonprez, P., Firat, E., Lindo, V., Greer, F., Davoust, J., Kratzer, R., Keller, S. R., Niedermann, G., & van Endert, P. (2009). IRAP identifies an endosomal compartment required for MHC class I cross-presentation. Science (New York, N.Y.), 325(5937), 213–217. https://doi.org/10.1126/science.1172845

Fruci, D., Giacomini, P., Nicotra, M. R., Forloni, M., Fraioli, R., Saveanu, L., van Endert, P., & Natali, P. G. (2008). Altered expression of endoplasmic reticulum aminopeptidases ERAP1 and ERAP2 in transformed non-lymphoid human tissues. Journal of Cellular Physiology, 216(3), 742–749. https://doi.org/10.1002/jcp.21454

Burgevin, A., Saveanu, L., Kim, Y., Barilleau, E., Kotturi, M., Sette, A., van Endert, P., & Peters, B. (2008). A detailed analysis of the murine TAP transporter substrate specificity. PloS One, 3(6), e2402. https://doi.org/10.1371/journal.pone.0002402

Firat, E., Huai, J., Saveanu, L., Gaedicke, S., Aichele, P., Eichmann, K., van Endert, P., & Niedermann, G. (2007). Analysis of direct and cross-presentation of antigens in TPPII knockout mice. Journal of Immunology (Baltimore, Md.: 1950), 179(12), 8137–8145. https://doi.org/10.4049/jimmunol.179.12.8137

Firat, E., Saveanu, L., Aichele, P., Staeheli, P., Huai, J., Gaedicke, S., Nil, A., Besin, G., Kanzler, B., van Endert, P., & Niedermann, G. (2007). The role of endoplasmic reticulum-associated aminopeptidase 1 in immunity to infection and in cross-presentation. Journal of Immunology (Baltimore, Md.: 1950), 178(4), 2241–2248. https://doi.org/10.4049/jimmunol.178.4.2241

Samino, Y., López, D., Guil, S., Saveanu, L., van Endert, P. M., & Del Val, M. (2006). A long N-terminal-extended nested set of abundant and antigenic major histocompatibility complex class I natural ligands from HIV envelope protein. The Journal of Biological Chemistry, 281(10), 6358–6365. https://doi.org/10.1074/jbc.M512263200

Saveanu, L., Carroll, O., Hassainya, Y., & van Endert, P. (2005). Complexity, contradictions, and conundrums: studying post-proteasomal proteolysis in HLA class I antigen presentation. Immunological Reviews, 207, 42–59. https://doi.org/10.1111/j.0105-2896.2005.00313.x

Saveanu, L., Carroll, O., Lindo, V., Del Val, M., Lopez, D., Lepelletier, Y., Greer, F., Schomburg, L., Fruci, D., Niedermann, G., & van Endert, P. M. (2005). Concerted peptide trimming by human ERAP1 and ERAP2 aminopeptidase complexes in the endoplasmic reticulum. Nature Immunology, 6(7), 689–697. https://doi.org/10.1038/ni1208

Gannagé, M., Abel, M., Michallet, A.-S., Delluc, S., Lambert, M., Giraudier, S., Kratzer, R., Niedermann, G., Saveanu, L., Guilhot, F., Camoin, L., Varet, B., Buzyn, A., & Caillat-Zucman, S. (2005). Ex vivo characterization of multiepitopic tumor-specific CD8 T cells in patients with chronic myeloid leukemia: implications for vaccine development and adoptive cellular immunotherapy. Journal of Immunology (Baltimore, Md.: 1950), 174(12), 8210–8218. https://doi.org/10.4049/jimmunol.174.12.8210

Saveanu, L., & van Endert, P. (2005). Dendritic cells: open for presentation business. Nature Immunology, 6(1), 7–8. https://doi.org/10.1038/ni0105-7