Immune receptors signaling in cancer and infection
We seek to understand how intracellular trafficking affects the activation and function of immune cells, including professional antigen-presenting cells and T cells. None of our results would be possible without innovative methods, including:
- High-resolution time-lapse microscopy
- Quantitative mass spectrometry of the dynamic association of proteins by proximity labeling
- Animal models to study the immune response in cancer and infection.
These methods are used to generate or validate new hypotheses about how the immune system works.
