Home on L. Saveanu lab

People

Sat, 29 Jun 2024 00:00:00 +0000

Loredana SAVEANU, MD, PhD, HDR, group leader

Loredana was trained as a medical doctor but switched to fundamental research. She started her career in the field of MHC-I (Major Histocompatibility Complex class I) antigen presentation, in which she identified a new class of antigen trimming enzymes and described novel cell biology mechanisms that allow MHC-I mediated presentation of exogenous antigens by dendritic cells (DCs). In 2015 she received the ATIP-Avenir award for French young researchers to start her independent team.

Irini Evnouchidou, PhD, senior scientist

Irini studied the role of ER aminopeptidases in antigen processing and presentation during her PhD in biochemistry in Greece. Her postdoctoral studies addressed the importance of aminopeptidases in T and antigen presenting cells. She showed, for example, that antigen T cell receptor (TCR) endosomal signaling is crucial for efficient anti-tumor T cell response. She is now interested in deciphering the molecular mechanisms by which endosomal pathways regulate TCR and related antigen receptor signaling.

Despoina Koumantou, PhD, post-doctoral fellow

Despoina performed her PhD in the NCSR “Demokritos” in Athens where she studied the effect of pharmacological inhibition of the aminopeptidase ERAP1 in the presented epitopes by MHCI molecules in an immunotherapy context. She was awarded a three-year funding by the FRM for a post-doctoral fellowship and joined the laboratory in February 2020. She investigates endosomal signaling by Fcγ receptors by using in situ biotinylation approaches, mass-spectrometry and functional assays.

Mathilde Nugue, PharmD, PhD candidate

Mathilde is working on molecular mechanisms by which autophagy pathways affect the antibody-dependent cellular cytotoxicity (ADCC) mediated by immunoglobulin receptors.

Klaus Hamäläinen, PharmD, PhD candidate

Klaus is investigating the role of a novel transcription factor in the neuroinflammatory response using cell biology, transcriptomics and mouse models of multiple sclerosis and Alzheimer's disease.

Marie d’Allemagne, research assistant

Marie contributes to most of the projects by coordinating mouse breeding, virus production, and managing the lab's cell and plasmid collections.

Matéo Ottaviani, research intern

Matéo investigates the cytotoxic activity of novel CAR-T cells enginnered by Irini.

Former lab members

Prakriti Karki, M2 Internship

Prakriti's project aims were to dissect the role of two serin-threonine protein kinases in the control of antigen receptor signaling and T cell activation.

Vivien Caillens, PhD candidate

Vivien explored the dynamics of protein complexes associated with the T-cell receptor through APEX2 labeling and quantitative mass spectrometry.

Eva Boisel, research assistant

Eva contributed to most of the projects, by coordinating mouse breeding, viral production and by managing the cell and plasmid collections of the laboratory.

Océane Morales, PharmD

Océane is a pharmacist by training, and she was looking to expand her knowledge on immunology by working on the molecular pathways leading to ITAM-coupled immune receptors activation.

Projects

Mon, 25 Dec 2023 00:00:00 +0000

Overview

Immune defense against intracellular pathogens and cancer cells depends on cytotoxic T lymphocytes. They are not alone and have evolved in the adaptive immune system to cooperate with myeloid cells and especially with dendritic cells, which are able to educate naive T lymphocytes. The T lymphocyte, initially naive and ignorant, once educated by the dendritic cell, becomes a powerful fighter capable of eliminating pathogen-infected or tumor cells. The communication between dendritic cells and T lymphocytes depends on two essential events:

Publications

Mon, 04 May 2026 00:00:00 +0000

2026

Saveanu L, Evnouchidou I. Methods for Analyzing Human T Cell Activation Through TCR or CAR Engagement. Methods Mol Biol. 2026;3007:291-299. doi: 10.1007/978-1-0716-5092-9_19. PMID: 41479017

2025

Gorline L, do Carmo FLR, Bourdely P, Bornères J, Vaudiau N, Semervil A, Vetillard M, Coulibaly ASK, Jugniot N, Ok A, Bausart M, Fiquet O, Andrade M, Fardol D, Haddar I, Abou Nader Z, Weber J, Theobald H, Collin M, Calmette J, Anselmi G, Fico F, Ginhoux F, Majlessi L, Gautier EL, Saveanu L, Helft J, Dalod M, Dusseaux M, Di Santo JP, Hugues S, Guermonprez P. Intratumoral delivery of FLT3L with CXCR3/CCR5 ligands promotes XCR1+ cDC1 infiltration and activates anti-tumor immunity. Nat Commun. 2025 Dec 30;17(1):1258. doi: 10.1038/s41467-025-68018-3. PMID: 41469380

News

Sat, 29 Jun 2024 00:00:00 +0000

June 2024 :

Researcher apprentice:

This year our team participated once again to the researcher apprentice’s initiative organized by the association “L’ arbre des connaissances”. Irini worked with Félix (15 years old) and Berenice (13 years old) from December to June in monthly 3 hour sessions where she allowed them to discover the magic world of CAR-T cells from CAR design and cloning till the expression in a T cell. Congratulations to Félix and Berenice for their presentation in the congress organized for all students participating to this initiative where they had the occasion to share their lab experience with their friends and family!

Contact

Thu, 11 Nov 2021 00:00:00 +0000

Antigen Presentation by Dendritic Cells to T cells (APreT)

Loredana SAVEANU

loredana.saveanu@inserm.fr

Center for Inflammation Research

UMR 1149 Inserm – Université Paris Diderot – ERL CNRS 8252

Faculté de médecine site Bichat 16 rue Henri Huchard F-75018 Paris FRANCE

Making the site

Sat, 21 Aug 2021 00:00:00 +0000

2020

If you reached this page, it was intended as a test for how pages could be generated as posts using Hugo.

2023

Hugo works really well for simple web sites, such as this one. Integrating a “news” part and a summary page is the next thing to do.